Continued expansion in the use of lungs donated after circulatory death

An international survey indicates a 20-fold increase over 14 years without compromising graft survival.

Data from the ISHLT registry on 22 lung transplant centers in North America, Europe and Australia reveals a dramatic expansion in the use of lungs donated after circulatory (cardiac) death (DCD ) – from 0.6% in 2003 to 13.5% in 2016 of all lungs transplanted (4). Not surprisingly, the vast majority of these DCD lungs (94%) were controlled DCD-III lungs (i.e. retrieved from donors under formal medical care). Of interest, 91% of all donors of DCD lungs were extubated as part of withdrawal of treatment, and about half received IV heparin.

Again, despite this rapid expansion in DCD-lung usage, a five-year follow-up demonstrated similar favorable long-term survival in DCD-III and conventional brain death-derived (DBD) lung donor recipients.

References:

4. Van Raemdonck D et al, Donation after circulatory death in lung transplantation-five-year follow-up from ISHLT Registry. J Heart Lung Transplant. 2019 Dec;38(12):1235-1245. doi:10.1016/j.healun.2019.09.007. (link to abstract)  

Xvivo Insights PB-2020-02-27