From lung to liver
Our final insight is an interesting study which suggests that STEEN solution, the well-established perfusate for ex-vivo lung perfusion (EVLP), seems to offer similar benefits in ex-vivo liver perfusion too. A recent comparative study(7) on pig liver transplant outcomes in which ex-vivo liver perfusion in a DCD model was performed with either STEEN solution, bovine-gelatin or packed red cells + plasma, revealed that livers perfused with STEEN solution scored highest outcome ratings in a broad battery of physiological parameters. The STEEN group displayed less graft injury – and improved liver function and survival after transplantation.
7. Linares-Cervantes I et al, Impact of Different Clinical Perfusates During Normothermic Ex Situ Liver Perfusion on Pig Liver Transplant Outcomes in a DCD Model. Transplant Direct. 2019 Mar 4;5(4):e437. doi: 10.1097/TXD.0000000000000876. eCollection 2019 Apr. (link to abstract)
Xvivo Insights PB-2019-06-27