Study on optimal oxygenation during EVLP wins JHLT´s “Best Basic Science” award

The study, (Noda et al, 2017, JHLT), focused on determining the optimal oxygen concentration of the perfusate during EVLP using a rat model of transplantation. They compared 6% oxygen (Toronto protocol) or 100% oxygen with intermediate levels of 40% oxygen or 60% oxygen. Based on parameters of lung function before and after EVLP and again after lung transplantation, they demonstrated that either too much (100%) or too little (6%) oxygen in the perfusate was detrimental to the graft. Lungs perfused with 40% oxygen had the best partial pressure of oxygen/forced inspiratory oxygen (PaO 2 /FIO2) ratio, pulmonary vascular resistance, and lung compliance.

The judges comment, “The study is a fantastic demonstration of the power of EVLP as a research tool for basic and translational research. The ability to carefully and rigorously test different aspects of a complex technique like EVLP is critical to the efficient and optimal clinical translation of such an amazing tool.”

Although the work was performed on a rat model which may restrict clinical translation, we congratulate the authors on this great achievement.

References:

3. (Noda et al, “Optimal ex vivo lung perfusion techniques with oxygenated perfusate” J Heart Lung Transplant (link to abstract)

4. 2017;36:466-474, Shaver CM, Diamond JM, Schrepfer S, Cantu E. Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017.  J Heart Lung Transplant. 2018 Feb 21. pii: S1053-2498(18)31361-5. doi: 10.1016/j.healun.2018.02.010. [Epub ahead of print]

Xvivo Insights PB-2018-05-20